Is there a connection between leptin and male infertility? 

By Setareh Tais, ND
Recently a study was published demonstrating a positive correlation between obesity, elevated serum leptin levels and male infertility. In the study, 66 infertile men were compared to 60 age-matched men with proven fertility. The results of the study demonstrated that infertile obese men had a statistically significant (p<0.001) higher serum leptin level (12 + 2 ng/mL) compared to normal weight, fertile men (7 + 1 ng/mL).  This supports prior studies demonstrating the role of leptin on the hypothalamic-pituitary-gonadal axis whereby elevated leptin (or leptin resistance) has been shown to negatively impact steroidogenesis, spermatogenesis and testicular physiology. This study should provide further encouragement to naturopathic doctors to consider weight management and dietary counseling as part of their management of obese, infertile men.Reference:
Farooq R, Lutfullah S, Ahmed M. Serum leptin levels in obese infertile men and women. Pak. J. Pharm Sci 2014. 27(1) 67-71.

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